On his blog, phpcult.com, today, Vidyut Luther has posted an update to his previous post asking where people usually define their settings.
function. This seems to address my problems with one large monolothic file pretty easily. I can still have a globals.conf.php which handles global settings, but I can also use this ini file, to load specific things that are only necessary for modules on an as needed basis. The global scope would be aware of the CONFIG_FILE constant, and I can parse specific sections of it whenever I need to.
My last post created a lot of conversation about how one should go about setting configuration options for your code. I realized, no one mentioned the use of PHP's built in parse_ini_file.
He notes that he'll try it in the next few days, but I imagine he'll like what he sees - especially if he's looking for a simple, external way to change information in a file and have it affect the entire app (without changing code).