On the PHPKitchen, Demian Turner shares exactly how he managed to get the Zend Debugger up and working on his Mac Book Pro.

Okay, there is some considerable hacking involved to get this working, and the solution is only a workaround until "sometime before the end of 2006", which was quoted to me by Zend as the time they expect to get the Zend debugger working for the mactel platform. No rush there guys.

His solution involved using Parallels Desktop, Zend Studio, a hack on the installer to get it working, ensuring it finds the right php.ini (a problem he had) and customizing the setup to work with the buttons of your choosing.