Rob Allen has posted a new entry on getting a Zend Framework application to run correctly even though mod_rewrite (or ISAPI_Rewrite) isn't up and running.
Some of our Zend Framework applications have to run on IIS without ISAPI_Rewrite installed. In these cases we need urls of the form http://www.example.com/index.php?module=mod&controller=con&action=act. I couldn't get this to work out of the box with Zend Framework 1.5, so wrote my own router called App_Controller_Router_Route_RequestVars.
Most of the post is the code for the router (ready for you to cut and paste) but he's also included a usage example of it so you can easily update your bootstrap file to use it.