Elvin Haci has a recent post to his blog showing how he set up PHP and Python to work on the same machine, just on different ports of the same Apache instance. His example is based on Ubuntu, but the principles can be used just about anywhere.

Today i decided to install Python in Ubuntu OS and to use PHP and Python both together. If i hadn't installed php and wanted to have python as only localhost in my OS, so it was easy, there are plenty of examples which show how to do it(for example). But if you have already installed php and you want to have python, then let's go on. Of course we need two different ports if we want to do so. And i could easily install and test it. So i am sharing how i did it.

He includes all of the commands and configuration changes you'll need to get Python and Apache all set up (he assumes you already have PHP installed). He also includes a full listing of his Apache config file so you can get a feel of how it all fits together using the VirtualHosts.