Paul Reinheimer has posted about some updates to a profiler project he's been working on, XHProf, with some new GUI improvements thanks to Highcharts. XHProf is a function-level hierarchical profiler for PHP and has a simple HTML based user interface.
I merged my Highcharts branch into master today, including a bunch of improvements to the GUI for XHProf including: using Highcharts for graphing URLs over time, which allows for multiple axis per graph, adding a pie chart to the individual run page to show where time was spent on page load, ability to merge various calls for display within the pie chart (e.g. mysql_* into mysql), switched to the javascript tablesorter for the single run results, filter to allow you to view results only from a specific server or domain
You can see two screenshots of this new feature in action here and here. If you'd like to give the tool a try, you can grab the latest version from github.