On NetTuts.com Jonathan Cutrell has posted some ideas for you to consider when designing your enterprise-level applications, regardless of the language(s) they're written in.

Organization can make or break the maintainability of an application. With smaller applications, organization is more obviously apparent; however, as the application grows and as the number of application developers and front-end engineers producing code increases, the more confusing organization can become. In this post, we will go over some basic concepts for keeping applications organized so that finding relevant code is an efficient and systematic process.

He's broken it up into a list of suggestions to make it a bit easier to take it all in:

• Learn from Frameworks
• Building a Standard
• Uniformity of Connected Parts, Uniqueness of Discrete Parts
• Another Note About Static Files
• What Should Be Unique?

There's some good advice in there, especially around things like standards, naming conventions, site complexity and how much usage the site is likely to see.