If you find yourself using Amazon SES for sending outgoing emails in a PHP web app, getting everything set up is much simpler than it may seem. In my case, this was on an AWS Linux image, but it will work on any Fedora/CentOS AMI. You can, of course, set up sendmail and use a proper MTA to send email from your web app, but in this case, I had inherited the requirement to set up an environment for code that was already written to use SES for outgoing email and Google Apps for incoming emails, so the actual mechanics weren't up for debate.
She includes screenshots showing how to configure the SES system with your site's domains and DNS as well as the email addresses you're planning on using. She links over to the MSMTP software you'll need to install on your instance to make the connection and what you'll need to do to get it configured for PHP's use. A sample email script is also included to test the connection (and where to look to make sure everything worked correctly).