On the Inside Open Source blog today, there's a "quick hit" post from Jason Gilmore for WordPress users out there using the WP-Cache and being frustrated by it's functionality during the development process.
I'm using WordPress to build out a blog for a new endeavor, and couldn't figure out why I had to go through a rather unwieldy refresh process (disabling a template and then enabling it anew) every time I changed it from within the WordPress administration interface.
It was the WP-Caching mechanism that WordPress comes with that was causing the issue, so he tracked down where to disable it for the duration of the development time. (Options -> WP-Cache -> Disable It).